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September 22, 2026

Analytical Strategies for Diastereomers in Oligonucleotide Development

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Phosphorothioate linkages are widely used in oligonucleotide therapeutics, but the resulting diastereomeric complexity presents important analytical and manufacturing considerations. This webinar explains why diastereomer distributions matter and introduces analytical approaches for their characterization, including HPLC fingerprinting, ³¹P NMR, and shortmer studies. Attendees will gain deeper insight into fingerprint methods and their application to the characterization and comparison of complex diastereomer mixtures.

 

Date: Tuesday, September 22, 2026

Time: 07:30 AM PT | 10:30 AM ET | 04:30 PM CEST

What You Will Learn

  • Why phosphorothioate linkages create diastereomeric complexity in oligonucleotide therapeutics
  • Why diastereomer distributions are an important consideration in oligonucleotide characterization
  • How analytical approaches, such as HPLC fingerprinting, ³¹P NMR, and shortmer studies, provide insight into diastereomer distributions
  • How fingerprint methods support the characterization and comparison of complex diastereomer mixture

Get to know the speaker

Speaker Highlight

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Nils Schomann
QC Manager Method Development

Nils Schomann has been a member of BioSpring's Method Development team since joining the company in 2021. He holds a Master of Science in Chemistry from Düsseldorf, Germany, bringing a strong scientific background to his role. Nils offers a unique perspective on the work behind method development at BioSpring, highlighting the scientific expertise and innovation that drive the team's work. His work in oligonucleotide analytics is shaped by the variety and technical complexity of the field, where new findings and technologies continue to create new opportunities for discovery and innovation. 

Audience

Who Should Watch This Webinar?

This webinar is intended for:

  • Biotech and pharma companies developing oligonucleotide therapeutics and evaluating phosphorothioate-linked molecules
  • CMC leaders focused on oligonucleotide characterization and method development
  • Researchers interested in advanced analytical approaches, including HPLC fingerprinting, ³¹P NMR, and shortmer studies
  • Teams seeking deeper understanding of diastereomer complexity and characterization of complex oligonucleotide mixtures

Reasons To Watch

Benefits of Watching

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Understand Diastereomer Complexity

Learn why phosphorothioate linkages create complex diastereomer mixtures and why diastereomer distributions matter in oligonucleotide characterization and therapeutics.

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Gain Insights into Fingerprint Methods

Understand how fingerprinting approaches support the characterization and comparison of complex diastereomer mixtures.

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Explore Analytical Characterization Approaches

Discover analytical approaches used to characterize diastereomer distributions, including HPLC fingerprinting, ³¹P NMR, and shortmer studies.

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Apply Insights to Oligonucleotide Characterization

Explore how analytical insights into diastereomer profiles support the characterization of complex diastereomer mixtures in oligonucleotide therapeutics.

Helpful Info

Frequently Asked Questions (FAQ)

Is the webinar free to watch?

Yes, registration is free and includes unlimited on-demand access.

In what language is the webinar presented?

The webinar is presented in English.

What if I have questions afterwards?

Reach out to us! Contact us here and we'll be happy to help.

Learn More

About BioSpring

Icon_BioSpring_30 years experience

Three decades of expertise

Industry leader in nucleic acid manufacturing and analysis since 1997​

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From research to commercial production

Global supplier of commercial oligonucleotides, supporting 9 commercial programs

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Trusted by pharma & biotech worldwide

APIs manufactured for hundreds of clinical trials worldwide

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One source for manufacturing & analytical solutions

Support at every stage, creating a long-lasting partnership