On-demand webinar
Analytical Strategies for Diastereomers in Oligonucleotide Development
Characterizing and comparing complex diastereomer mixtures
Explore why diastereomer distributions matter and how HPLC fingerprinting, ³¹P NMR and shortmer studies support their characterization.
About this webinar
Phosphorothioate linkages are widely used in oligonucleotide therapeutics. The resulting diastereomeric complexity presents important analytical and manufacturing considerations. This webinar explains why diastereomer distributions matter and introduces approaches for characterizing and comparing complex mixtures.
What you’ll learn
- Why phosphorothioate diastereomer distributions matter in oligonucleotide development.
- HPLC fingerprinting approaches for characterization and comparison.
- The contribution of phosphorus-31 NMR and shortmer studies to the analytical assessment.
Who is it for?
Scientists and teams working in oligonucleotide analytical development, characterization, process development and quality control.